• ​​Optogenetic control of Protein Kinase C-epsilon activity reveals its intrinsic signaling properties with spatiotemporal resolution.

Ong Q, Yi Lim CJ, Liao Y, Tze-Yang Ng J, Rachel Lim LT, Yi Koh SX, En Chan S, Yu Ying PL, Lim H, Ye CR, Wang LC, Ler SG, Sobota RM, Sing Tan Y, Shulman GI, Yang X, Han W.

bioRxiv [Preprint]. 2025 Jan 6:2025.01.06.631444. doi: 10.1101/2025.01.06.631444.

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• Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT.
  Ong Q, Lim R, Goh C, Liao Y, Chan SE, Lim C, Kam V, Yap J, Tseng T, Desrouleaux R, Wang LC, Ler SG, Lim SL, Kim S, Sobota RM, Bennett AM, Han W, Yang X (2024)
  Nature Chemical Biology  doi: 10.1038/s41589-024-01770-7
   

•  Amino acid is a major carbon source for hepatic lipogenesis.
  Liao Y, Chen Q, Liu L, Sun J, Huang H, Bai X, Jin C, Li H, Sun F, Xiao X, Zhang Y, Li J, Han W, Fu S (2024)
  Cell Metabolism 36(11):2437-2448.e8. doi: 10.1016/j.cmet.2024.10.001
   

• Up-regulation of SLC7A11/xCT creates a vulnerability to selenocystine-induced cytotoxicity.
  Tan SLW, Tan HM, Israeli E, Fatihah I, Ramachandran V, Ali SB, Goh SJA, Wee J, Tan AQL, Tam WL, Han W (2023)
  Biochemical Journal 2023 Dec 20;480(24):2045-2058. doi: 10.1042/BCJ20230317
   

• Schizophrenia-like behaviors arising from dysregulated proline metabolism are associated with altered neuronal morphology and function in mice with hippocampal PRODH deficiency.
  Yao Y, Jin C, Liao Y, Huang X, Wei Z, Zhang Y, Li D, Su H, Han W*, Qin D*(2023) 
  Aging and Disease 15(4):1-17. September 25, 2023. DOI: 10.14336/AD.2023.0902
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• Genetic ablation of LAT1 inhibits growth of liver cancer cells and downregulates mTORC1 signaling.
  Kim S-Y, Ong Q, Liao Y, Ding Z, Tan AQL, Lim LTR, Tan HM, Lim SL, Lee QY, Han W (2023)
  International Journal of Molecular Science 24(11):9171 https://doi.org/10.3390/ijms24119171
   

• Paired box 6 programs essential exocytotic genes in the regulation of glucose-stimulated insulin secretion and glucose homeostasis.
  LSo WY, Liu WN, Teo AKK, Rutter GA, Han W (2021)
  Sci Transl Med 2021 Jun 30;13(600):eabb1038. doi: 10.1126/scitranslmed.abb1038. PMID: 34193609
   

• HOXC10 suppresses browning to maintain white adipocyte identity.
  Tan HYA, Sim MFM, Tan SX, Ng Y, Gan SY, Li H, Neo SP, Gunaratne J, Xu F, Han W (2021)
  Diabetes 2021 Aug;70(8):1654-1663. doi: 10.2337/db21-0114. Epub 2021 May 14. PMID:33990396; PMCID: PMC8385616
   

• Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis.
  Ding Z, Ericksen RE, Escande-Beillard N, Lee QY, Loh A, Denil S, Steckel M, Haegebarth A, Wai Ho TS, Chow P, Toh HC, Reversade B, Gruenewald S, Han W (2020)
  J Hepatol 2020 Apr;72(4):725-735. doi:10.1016/j.jhep.2019.10.026. Epub 2019 Nov 11. PMID: 31726117​​​​​​​​